His father, Maqsood Ahmed Shaikh, served in top positions in the Government of Pakistan.

Noshad acquired his MBBS degree from the University of Karachi in 1983, where he did postgraduate work in general surgery.

He has worked as professor of surgery at Dow University of Health Sciences, Karachi along with various administrative capacities including the posts of medical superintendent, Lyari General Hospital and Civil Hospital Karachi.

He was the pioneer architect in the development of Safe Blood Transfusion Act 2006, Private Hospitals Regulatory Authority bill and the telemedicine project in the province of Sindh.

Under his leadership, Liaquat University of Medical and Health Sciences Jamshoro became the first public sector medical institution in the country to introduce biomedical ethics and IT as subjects in the undergraduate syllabus.