Nosy Mitsio is an island off the northwest coast of Madagascar.

Owing to the Mitsio archipelago being distant from other large bodies of land, Nosy Mitsio offers crystal clear waters, white sandy beaches, lush coconut palms and a marine fauna with abundant reefs distant from the island perimeter.

Nosy Mitsio is very rural: it has no infrastructural development and is populated mainly by small family villages, that belong to the municipality of Antsohimbondrona.

Most inhabitants of Nosy Mitsio are subsistence rice farmers who also use a variety of fishing methods and shellfish gathering.

Supplemental income is provided through salting fish, diving for sea cucumbers, and gathering coconuts - all of which is sold at Port St Louis, the nearest port on mainland Madagascar.