Nothobranchius sainthousei is a species of brightly red- and blue colored seasonal killifish in the family Nothobranchiidae.

[2] It was named in honour of Ian Sainthouse, a "renowned breeder and collector of killifish, for his special longstanding dedication to researches on the genus Nothobranchius".

As with all members of the genus Nothobranchius, they show extreme life-history adaptations: their embryos survive by entering a three to four month long diapause,[5] within eggs that have a very hard chorion and are resistant to desiccation and hypoxia.

[2] The holotype is a 32.9 mm long male specimen preserved at the Royal Museum for Central Africa, filed under the ID "MRAC B5-027-P-0001".

It was collected on April 6, 2012 by the Hungarian ichthyologist Béla Nagy and the Danish breeder and collector Finn Christian Milvertz.