The nightly early-evening newscast focusing on international news and stories of relevance to the network's main target demographic of Hispanic and Latino Americans.

The program's late weeknight editions, "Noticias Telemundo: En La Noche" (Spanish for 'Telemundo News: At the Night') is currently anchor by Arantxa Loizaga (appointed from network's morning show Hoy Día in 2022), and before Julio Vaqueiro.

The program was produced through an outsourcing agreement with the Miami-based Hispanic-American Broadcasting Corporation, which based the half-hour newscast from a converted warehouse in Miami.

In 1996, following the sale of Telenoticias – a Latin American cable news channel created in 1994 as a joint venture between Telemundo, Argentinean television network Artear, Spain broadcaster Antena 3 and Reuters – to CBS Cable due to low viewership and monetary losses on the venture,[5][6] Telemundo entered into a content partnership with the channel to take over production of the broadcast network's early-evening and prime time newscasts.

[7] On August 25, 1999, CBS Telenoticias announced that it would not renew production outsourcing agreement with Telemundo upon the expiration of their four-year contract on December 31.

[9] The program established itself early on through various special project reports including "Crónicas de la Frontera" ("Chronicles from the Border"), in which correspondent Gustavo Mariel profiled immigrants risking their lives to cross into the United States–Mexico border to seek a better life, and "Ecstasy Un Viaje al Infierno" ("Ecstasy, A Voyage into Hell"), looking into the dangers of the party drug Rohypnol.

On December 14, 2009, Sevcec announced his departure from Noticiero Telemundo and the network's news division, effective immediately; José Díaz-Balart (who had been serving as a co-host and news anchor for the morning program Cada Dia with María Antonieta ("Every Day with Maria Antonieta") until it was cancelled in May 2008) was named as his replacement and took over as main anchor on December 15; Diaz-Balart would subsequently add a new weekly Sunday morning talk show Enfoque to his duties in February 2010.

The program would return to using a two-anchor format on May 15, 2013, when Noticias Telemundo announced that María Celeste Arrarás would become Diaz-Balart's co-anchor on the program, while remaining anchor of Al Rojo Vivo; the move came after the news division appointed Arrarás to serve as an occasional co-anchor alongside and substituting for Diaz-Balart on the newscast beginning the previous December.

Telemundo would not air a scheduled weekend edition of the newscast until Saturday, December 15, 2012, when it aired a special edition of Noticiero Telemundo – presented by main anchors José Díaz-Balart and María Celeste Arrarás – focusing on the Sandy Hook Elementary School shooting, followed by an hour-long tribute special on singer Jenni Rivera, Jenni Siempre Vivirá, which provided details on the investigation into the plane crash that killed Rivera and eleven others on-board near Monterrey, Mexico, en route from a concert performance on December 9, interviews with Rivera's family, other celebrities and fans.

In announcing the expansion, then-executive vice president of news and alternative programming Alina Falcón stated that the addition of Noticiero Telemundo Fin de Semana "further confirms our commitment to inform our audience seven days a week, all year long."

[20][21] The weekend editions may occasionally be preempted due to Telemundo Deportes soccer and hockey telecasts that are scheduled to air within the program's normal time slot.