Nucleocidin is a fluorine-containing nucleoside produced by Streptomyces calvus.

[1] Nucleocidin stems from the ribonucleoside adenosine[2] - is unique because it possess two rare functional groups: a fluorine atom and a sulfamyl ester [3] During 1968 the attempts to identify nucleocidin were made and at that time it was assigned to a structure of a 9-adenyl-4' -sulfamoyloxypentofuranoside, which was mainly based on experiments from NMR and mass spectrometry, as well as testing in chemical reactions.

[4] Nucleocidin is an antibiotic produced from Streptomyces calvus.

Though toxic to mammals, it is able to function against bacteria both gram negative gram positive.

[6] The compound is capable of interrupting the synthesis of peptides.