[1] The natural hosts of species in this family are invertebrates, among them winged insects (Lepidopterans, Hymenopterans, Dipterans), and decapods.

However, species in this genus have been isolated only from the insect order Lepidoptera.

[3][4][5] The following species are assigned to the genus:[5] Viruses in Alphabaculovirus are enveloped, with circular genomes around 80–180 kbp in length.

The virus exits the host cell by nuclear pore export and exists in occlusion bodies after cell death, remaining infectious until finding another host.

Winged insects, arthropods, Lepidoptera, Hymenoptera, Diptera, and Decapoda serve as natural hosts.