Nude Nuns with Big Guns is a 2010 nunsploitation vigilante action film directed by Joseph Guzman and starring Asun Ortega, David Castro, and Perry D'Marco.

Acquiring heavy weapons (including big guns and vibrators), Sister Sarah sets out to kill those who had abused her and are using the church for their own personal gain.

After being wounded in a shootout, Sister Sarah hides out in a fleabag motel where she recovers and finally achieves vengeance by killing Los Muertos, emasculating the gang's leader Chavo, and saving her female lover who had been raped.

But in the final scene, the cardinal drug lord, known only as the Monsignor, hires another hit man to track down the vigilante nun, setting up a sequel hook.

[6] Felix Vasquez Jr. of Cinema Crazed gave the film a positive review, praising the lead performance of Asun Ortega, and called it "a fun and demented revenge pic that will surely please any respecting grindhouse buff".