Nueva Ocotepeque is in a north-south valley 5 kilometres (3.1 mi) north of the El Salvador border, and 13 kilometres (8.1 mi) east of the Guatemala border.

The north 140 metres (460 ft) of the runway have trees encroaching on the east side.

The Ilopango VOR-DME (Ident: YSV) is located 44.6 nautical miles (82.6 km) south of the airport.

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