The series originally premiered on September 12, 2011, as Numbers Never Lie; initially co-hosted by Charissa Thompson, the program focused primarily on statistics and analytics (hence its name) and was positioned as being of interest to fantasy sports fans.

According to Smith, ESPN's staff felt that viewers were being alienated by the program's focus on "hard analytics".

[1] Thompson left Numbers Never Lie in June 2012 to take over the co-host's role on SportsNation, and Smith was joined by rotating guest analysts until Rose and Douglas became permanent cohosts on September 10, 2012.

On August 13, 2013, ESPN parted with Hugh Douglas following an altercation with co-host Michael Smith.

[5] On October 11, 2016, ESPN announced that Smith and Hill had been promoted to hosting a re-launched evening edition of SportsCenter, SC6 (replacing Lindsay Czarniak, who was going on maternity leave and was originally to return in a different role at ESPN afterward, but decided to depart ESPN and began doing work for other networks, including Netflix and Fox Sports), beginning on February 6, 2017, and that His & Hers would be eventually discontinued.