[4] Nwe made her acting debut with a leading role in the film Kawei Choe Tae Phel, alongside Zay Ye Htet in 2015.
In 2018, she starred in the comedy drama Mingalar Shi Tae Ayet, alongside Myint Myat, Nay Dway and Aye Wutyi Thaung.
[7][8] The same year, she was cast in the big-screen film Kyal Ma Shi Tae Kaung Kin (Starless sky ), where she played the main role with Phupoom Pongpanu, Nay Toe, Sai Sai Kham Hlaing, Tun Tun, Emi Takei, Aye Myat Thu and Moe Set Wine.
Following the 2021 Myanmar coup d'état, Nwe Darli Tun was active in the anti-coup movement both in person at rallies and through social media.
Along with several other celebrities, she was charged with calling for participation in the Civil Disobedience Movement (CDM) and damaging the state's ability to govern, with supporting the Committee Representing Pyidaungsu Hluttaw, and with generally inciting the people to disturb the peace and stability of the nation.