Nyagatare lies in an area of grassy plains, and low hills, with excellent views in all directions, including the mountains of southern Uganda and, on a very clear day, the Virunga volcano range.

The District of Nyagatare is characterized, in general, by lowly inclined hills separated by dry vallies for a long period of the year (June–October).

This kind of topographical layout constitutes an important potentiality for modern and mechanized agriculture.

Few of the rivers found there such as Nyiragahaya, Kayihenda, Karuruma, Nayagasharara and Kaborogota are erratic and intermittent.

The weak river network constitutes a serious handicap to responding to the needs of water for people and animals.

The District of Nyagatare contains half of Akagera National Park where is found a vast number of wildlife including African buffalo, antelopes and more other ruminants.

Hares, wild boar, monkeys and other rodents are occasionally found in the wooded savanna.

The flora in Nyagatare is made in general by an afforested savanna vegetation and gallery forests along the rivers.

These types of soils may be exploited with the help of modern agricultural techniques and form sorts of artificial pastures camps for livestock.