The O. Henry is named after American writer and Greensboro native William Sydney Porter, whose pen name was O. Henry.

The original hotel building, which was located in downtown Greensboro, was built in 1919 on the corner of Bellemeade and North Elm Street.

It was demolished in 1979[1] and a new hotel building was built in the late 1990s two miles from the original location.

The O. Henry is privately owned by Quaintance-Weaver Restaurants & Hotels.

The O. Henry is home to the restaurant the Green Valley Grill.