It passes through Bryan, Wauseon (where it briefly becomes a couplet[5]), and enters greater Toledo west of its interchange with the Ohio Turnpike.

From Oregon to Sandusky SR 2 is part of 293 miles (472 km) of the highway designated the "Lake Erie Coastal Ohio Trail".

Near Elyria, it joins Interstate 90 (I-90), whose route it shares to Rocky River, where it follows SR 254 along Detroit Road into Lakewood.

SR 2 serves as an access route to lakeshore attractions on Lake Erie from Toledo and Cleveland and as an alternative to the Ohio Turnpike.

[9] The section of SR 2 that runs through Willoughby is named "Brian Montgomery Memorial Highway"[10] in honor of a Marine Lance Corporal who was killed in the Iraq War in August 2005.