OSF Saint Anthony Medical Center is a hospital located in Rockford, Illinois, USA.

On July 1, 1899, six of the Sisters of the Third Order of St. Francis moved to Rockford at the request of the citizens to open a hospital.

[1] With the help of the real estate agent William Crotty, the sisters were able to purchase a house on the corner of East State St. and Summit St. Community members donated the supplies and furniture for the first hospital.

[4] Since 1981, the Lifeline Emergency Helicopter Service has been based at Saint Anthony.

[7] OSF SAMC surgeons perform 60% of open heart surgery cases in Rockford, making OSF SAMC the community leader in open heart surgery.