Oak Orchard WMA, along with the Iroquois National Wildlife Refuge and the Tonawanda Wildlife Management Area farther to the west, helps form a continuous conservation and management zone, the Alabama Swamp Complex, covering part of three counties.

The Oak Orchard WMA is located about halfway between Buffalo and Rochester.

The western boundary is marked by Knowlesville Road, which separates the WMA from Iroquois National Wildlife Refuge.

Most of the pedestrian traffic in the WMA is along the dikes that separate the wetland into discrete marshes.

Permissible activities at Oak Orchard WMA include hunting, fishing, non-motorized boating, hiking and nature study, bird watching, cross-country skiing and snowshoeing.