Oak Ridge is a village in the southern part of Apple Creek Township in Cape Girardeau County, Missouri, United States.

As the name implies, the village is built on a high ridge, which is a drainage divide between the Apple Creek and Whitewater River watersheds, and surrounded by oak trees.

[4] Andrew Ramsay and Alexander Giboney settled in the area around Ramsey Creek in 1795.

The community of Oak Ridge was organized in 1852 by John M. Wilson, who purchased the land at $2.50 per acre and established a store and a bar.

The first high school in Southeast Missouri was established in Oak Ridge in 1874.

[6] Oak Ridge's high school began classes on November 4, 1874, at a frame building contained four rooms.

[7] The Oak Ridge R-6 School District is a small, public secondary education facility that runs throughout much of northern Cape Girardeau County.

With an average yearly enrollment of 350 students in grades K-12, it is one of the smaller public schools in Southeast Missouri.

According to the United States Census Bureau, the village has a total area of 0.57 square miles (1.48 km2), all land.