Oberwesel station is on the West Rhine Railway (German: Linke Rheinstrecke) between Koblenz and Mainz in the UNESCO World Heritage Site of the Upper Middle Rhine Valley in the German state of Rhineland-Palatinate.

[1] It is in the southern part of the town of Oberwesel and is served by Regional-Express services operated by Deutsche Bahn and Regionalbahn trains operated by trans regio Deutsche Regionalbahn.

Oberwesel station was opened with the extension of the West Rhine Railway from Koblenz to Bingen at the end of 1859.

In 1925–1927, the lobby was renovated and a separate toilet block was constructed on Mainzer Straße.

Oberwesel station is served by the following regional services: Additional excursion trains run on Sundays and public holidays from May to October.