[2] OMSC began as a barangay high school founded in 1966 and is now a full-fledged state college with six campuses catering to more than eight thousand students of the province and nearby municipalities.

The concept was carried out by Sofronio Fadre, Schools Division Superintendent, and Mariano Ramirez, East District Supervisor.

Education, Culture and Sports Minister, Lourdes R. Quisumbing appointed Virginia A. Sicat, who was then assistant principal of the OMSC, as officer-in-charge of the institution on 1 April 1986.

The state college established the following service areas in San Jose, Occidental Mindoro: In the year 2000, by virtue of Republic Act 8760 (also known as the General Appropriations Act) significant reforms were brought about in the educational system, specifically to OMSC.

It became the host to CHED-supervised institutions in the province, namely the Occidental Mindoro Polytechnic College (OMPC) in Murtha, San Jose, Occidental Mindoro and the Pedro T. Mendiola Sr. Memorial Technological and Polytechnic College in Brgy.

After 15 years of sterling and dedicated service to the Institution, Sofronio S. Sanqui, the second college president, retired.

Three months to Venturina’s presidency, President Gloria Macapagal-Arroyo signed RA 9747, also known as an “Act Renaming Occidental Mindoro National College as the Occidental Mindoro State College”, on 10 November 2009,[4] whose principal sponsor was Congresswoman and Deputy Speaker, Amelita C. Villarosa.