Octamerella is an extinct genus of prehistoric nautiloids from the oncocerid family Hemiphragmoceratidae that lived in what is now Europe and North America during the Middle Silurian.

Octamerella has a breviconic shell and a mature aperture that is contracted so as to have four pairs of dorsolateral sinuses, four on each side, and a narrow mid-dorsal salient.

The two ventral-most sinus pairs are typically the largest, while the dorsal-most pair is short and wide, forming a circular opening.

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