The first station in Odense, now demolished, opened in 1865 as the railway line across the island of Funen was completed.

[6][7] The first one, now demolished, opened in 1865 with the rest of the railway line across Funen (Dronning Louises Jernbane).

The first station building was designed by the Danish architect Niels Peder Christian Holsøe, known for the numerous station buildings he designed across Denmark in his capacity of head architect of the Danish State Railways.

[8][9] Historically, Odense station has been the central hub of railways on Funen, being the terminus for a handful of now closed railways:[10] The stations offers services to Copenhagen, Esbjerg, Aarhus, Svendborg and international service to Hamburg (Germany).

The Danish Railway Museum is located in the roundhouse immediately north of Odense station.