Odesa National Polytechnic University (Ukrainian: Національний університет «Одеська політехніка», romanized: Natsionalnyi universytet «Odeska politekhnika») is a Ukrainian public institution of higher education and research in Odesa, Ukraine.

Among its graduates are many talented engineers, scientists, heads of scientific organizations and universities, top management staff at different industries, as well as political actors.

Nowadays, the university represents a huge training center of high-qualification personnel in the south Ukraine.

The Odesa National Polytechnic University structure includes 11 institutes, ten faculties, 62 departments, technical school and college.

At the rating calculated annually among more than 400 Higher educational institutions and Universities of Ukraine (evaluated by the International Staff Academy and the Ukraine Academy of Pedagogy) the Odesa National Polytechnic University holds 15–18 rates and during last five years is rated steadily in the number of TOP TEN from among technical and technological Ukrainian Universities.