The school, today known as the Ohio School for the Deaf, sat on the present-day Topiary Park grounds in the modern-day Discovery District.
The main school building was gutted by a fire on October 2, 1981, though an existing building still stands as Cristo Rey Columbus High School.
The school was founded in 1829 as the Ohio Institution for the Education of the Deaf and Dumb.
Within a few decades, the school purchased 10 acres (4 ha) on East Town Street.
An additional building, the current Cristo Rey Columbus High School, was completed in 1899.