Its southern terminus is at SR 7 in Gallipolis, and the route heads north.

It meets U.S. Route 35 at an interchange with various collector and distributor ramps.

[1] From there, the route passes through Vinton in northern Gallia County.

Following an intersection with SR 32, the route heads in a more westerly direction until it meets and its northern terminus is at State Route 93 in Hamden.

Original route certified; routed from 3 miles (4.8 km) north of Gallipolis to Hamden along the previous alignment of State Route 142 from 3 miles (4.8 km) north of Gallipolis to 4 miles (6.4 km) north of Radcliff, and along a previously unnumbered road from 4 miles (6.4 km) north of Radcliff to Hamden.