The southern (eastern) terminus of SR 169 is at a signalized intersection with U.S. Route 422 (US 422) just east of Niles.

From its southern terminus at US 422 and Tibbetts Wick Road, SR 169 heads west along the two-lane Robbins Avenue in Weathersfield Township through a mostly residential neighborhood.

About 1⁄3 mile (0.54 km) in, it enters the city of Niles and gains a center turn lane.

The highway becomes four lanes wide as it passes under a pair of railroad bridges.

After entering the city of Warren, it passes Oakwood Cemetery and crosses a railroad at-grade before ending at the intersection of US 422 (South Street) and Chestnut Avenue.