Its southern terminus is SR 800 in Sandy Township, approximately 0.5 miles (0.80 km) east of Sandyville and less than two miles (3.2 km) south of East Sparta.

Its northern terminus is SR 14 in Edinburg Township near Interstate 76, about 10 miles (16 km) southeast of Ravenna.

In 1937 the portion of the road between Alliance and U.S. 224 was made part of State Route 225 and the portion of SR 80 between Alliance and Atwater was rerouted further west, following State Route 619 west from Alliance and then turning north on Atwater Avenue NE, passing through Limaville and continuing to the junction with U.S. 224 in Atwater Center.

[9] In 1948, the portion between Limaville and Alliance was rerouted along the current SR 183 alignment using Iowa Avenue NE heading northeast from Alliance, passing through the western edge of Limaville.

[10] The short 0.5-mile (0.80 km) cosign with U.S. 224 in Atwater was added in 1958 as part of a realignment of U.S. 224 between Atwater and Akron that constructed a separate highway to parallel Waterloo Road.