The southern terminus of SR 222 is at U.S. Route 52 (US 52) in the village of Chilo.

Its northern terminus is at a signalized T-intersection with US 50 approximately 3.50 miles (5.63 km) northwest of Batavia.

The entirety of SR 222 is situated within Clermont County.

No section of this state route is included within the National Highway System (NHS), a network of highways that are deemed most important for the economy, mobility and defense of the nation.

Originally, the highway was routed from its present southern terminus in Chilo to its junction with the former SR 25 in Monroe Township.