The state route begins at an intersection with SR 232 within a valley formed by the Big Indian Creek.

First heading southeast, it crosses over the aforementioned creek and climbs a hill.

At the top, the terrain flattens out and SR 756 continues heading southeast towards Felicity.

The two routes run together until they reach North Market Street, which carries SR 133.

After entering Lewis Township, Brown County, the route makes an S-curve towards the southeast but quickly returns to a northeastern bearing.