Situated in southern Clermont County, SR 743 came into existence in the late 1930s when many highways numbered in the 500s, 600s and 700s were designated throughout Ohio.

SR 743 overlaps US 52 heading south for nearly zero point four miles (0.64 km) into rural Washington Township.

The state highway then splits from US 52, and heads east into a predominantly forested setting, with the occasional house appearing along the side of the roadway.

Continuing northeast, SR 743 passes a mix of grassy fields and tree patches, with houses appearing here and there.

Ultimately, SR 743 turns due east, and follows this path to its intersection with Bees Run Road in the residential hamlet of Point Isabel.