SR 253 runs exclusively within Green Township in southeastern Scioto County, near the community of Franklin Furnace.

This short highway starts at the Kentucky state line on the two-lane Jesse Stuart Memorial Bridge over the Ohio River, at the very point where KY 10 terminates.

[4] On a regular basis, the Ohio Department of Transportation (ODOT) conducts surveys to measure the amount of traffic that uses its highway system.

At the time, in the northern half of Medina County, a segment of what is now county-maintained Fenn Road between the SR 18/SR 57 concurrency and U.S. Route 42 was brought into the state highway system.

[10][11] SR 253's time of being routed along this stretch of roadway came to an end in 1958 when jurisdiction of Fenn Road was transferred from the state to Medina County.