The southern terminus of this state route is at a signalized intersection that marks the western split of the concurrency of SR 18 and SR 57 nearly 1.25 miles (2.01 km) northwest of the city limits of Medina.

SR 252 has its northern terminus at a T-intersection with U.S. Route 6 (US 6) in the western Cleveland suburb of Bay Village.

Along its path, SR 252 travels through northern Medina County, the extreme eastern portion of Lorain County and the westernmost part of Cuyahoga County.

There are no stretches of SR 252 that are included as a part of the National Highway System.

[4][5] One year later, the highway was extended north to its current northern terminus.