The highway heads through rolling terrain making sweeping curves before reaching a four-way intersection marking the northern terminus of SR 792.

SR 266 heads south from this intersection through farmland but then closely follows the river where it passes a state memorial commemorating the Big Bottom massacre.

After a sharp curve to the north to follow the river, the highway heads through a mostly wooded area passing some houses and a farm.

[4][5] Beginning in 2016, a portion of the road east of Stockport located close to the Muskingum River bed was slated for removal due to the constant need for repairs of landslides and rock falls.

[9] The 1.065-mile (1.714 km) former alignment of the highway located closer to the river has been designated by ODOT as SR 266-J, with the "J" suffix meaning the road is to be eventually abandoned by the state.