The western terminus of SR 507 is at U.S. Route 68 (US 68) one mile (1.6 km) south of West Liberty.

Its eastern terminus is at SR 245 near the Ohio Caverns approximately four miles (6.4 km) southeast of West Liberty.

A T-intersection with US 68 in Salem Township located approximately one-half mile (0.80 km) south of the boundary between Champaign and Logan counties, and one mile (1.6 km) south of West Liberty, marks the starting point of SR 507.

Heading east from there, this state route jogs northeasterly briefly before continuing easterly through farm country.

Passing its intersection with McClain Road, SR 507 turns to the southeast.