Its eastern terminus is at SR 753 in another unincorporated community, Carmel.

It follows a reverse curve to the north, then takes on an east-northeasterly path into rural Marshall Township, dominated primarily by open fields.

Passing by a few patches of trees amid the open land, SR 506 next comes to back-to-back intersections with McCoppin Mill Road (CR 51) and Slate Hill Road (CR 77).

At this point, as SR 506 has passed into Brush Creek Township, a pair of thicker patches of woods abut the north side of SR 506, which then re-enters fully into farmland.

The only change that has occurred along SR 506 since its inception is the route that it intersects at its eastern terminus.