At a length of just shy of five miles (8.0 km), SR 537 is located entirely within southwestern Monroe County.

The state route's western terminus is at SR 260 approximately three and a half miles (5.6 km) southeast of the unincorporated community of Sycamore Valley, and its eastern terminus is at SR 26 one mile (1.6 km) south of the village limits of Graysville.

SR 537 begins at the rural southwestern Monroe County intersection of SR 260 and County Road 68 (CR 68), the latter also called Big Injun Road, approximately three and a half miles (5.6 km) southeast of Sycamore Valley in the hamlet of Marr.

For its entire length, the state highway follows a hilly, curvey routing through Wayne National Forest, with the occasional home and patch of open space.

After crossing CR 73, the state highway turns back to the southeast, then bends back north, and finally to the northeast as it arrives at its junction with SR 26, a T-intersection located one mile (1.6 km) south of Graysville that serves as its endpoint.