State Route 260 (SR 260) is a 36.67-mile-long (59.01 km) state highway in southeastern Ohio.

The route is signed as a north–south highway though it runs northwest–southeast between Matamoras and East Union.

[3] SR 260 was first assigned around 1926 on its present alignment between SR 145 in Road Fork to SR 78 near East Union, entirely in Noble County.

By 1933, SR 260 extended east from SR 145 in Monroe County to the community of Marr.

[6][7] Within the next two years, the route was extended south to Bloomfield and absorbed all of SR 245.