The route's southern terminus is at a diamond interchange with the U.S. Route 33 (US 33) expressway approximately three and a half miles (5.6 km) southeast of Logan.

The state highway travels through the counties of Hocking and Perry along its way.

No part of SR 595 is incorporated in the National Highway System.

[2] SR 595 was created in 1937 along the routing that it maintains to this day through eastern Hocking County and extreme southern Perry County.

The highway has not experienced any major changes to alignment since it was established.