Most of the route is a rural two-lane highway and passes through farmland, woodland, and residential properties.

The route heads east passing through farmland and residential properties, on the south edge of Wakeman.

After Wakeman the highway curves southeast passing through woodland and farmland, crossing over the Vermillion River.

After the tracks the road leaves LaGrange and crosses over the East Branch of the Black River.

After Valley City, the road enters Brunswick, passing through residential properties, having an intersection with US 42.

East of US 42, SR 303 becomes a four-lane highway with a center turn lane, passing through commercial properties.

East of I–71 the route returns to a four-lane highway with a center turn lane, still passing through commercial properties.

After I–271 the road roughly parallels the Ohio Turnpike to the south, passing through the Cuyahoga Valley National Park.

The route leaves Hudson and enters Streetsboro, passing through residential and commercial properties.

The route crosses over the Cuyahoga River, before an intersection with SR 44 at the center of Shalersville.

East of Windham the road passes through woodland, with houses, before crossing the Ohio Turnpike.