SR 625 begins at the signalized intersection of US 224 and Tippecanoe Road in Boardman Township.

Known as Lockwood Boulevard, SR 625 begins in a northeasterly direction, passing through a commercial district up through its intersection with Tippecanoe Road, which turns off to the northwest.

Eventually, a residential cul-du-sac, an apartment complex, and then the Mill Creek Park Golf Course appear on the east side of SR 625.

Continuing to the northeast, SR 625 passes by a number of homes and scattered patches of woods, before intersecting Truesdale Road.

With houses lining both sides of the route, SR 625 continues north for a short distance, curving slightly to the north-northwest as it enters into the signalized T-intersection with US 62 that marks its endpoint.