The road also remains within 10 miles (16 km) of the Pennsylvania state line for the northern portion.

Once it reaches the Pennsylvania border it heads north along SR 11 & US 30 from East Liverpool to Rogers.

Upon reaching the junction with the Ohio Turnpike, OH SR 7 enters the Connecticut Western Reserve.

Continuing north, it becomes Market Street in Boardman, Ohio, with a significant suburban increase.

After that shared alignment, the highway then heads north again in Hubbard through many small towns to its northern terminus with SR 531 in Conneaut.

In 1912, Intercounty Highway 7 ran along the Ohio River, from Elizabethtown to the Pennsylvania state line in East Liverpool.

[6] In 1927, the route's southern terminus was truncated from the Indiana state line to Chesapeake to make way for US 52 and a small segment of US 50[7] A tunnel was constructed north of Stratton in 1982.

The original eastern terminus of the four-lane divided highway was at the current Chesapeake northbound-only exit ramp east of Tallow Ridge Road.

[10] US 52 originally crossed at the present-day Robert C. Byrd Bridge that connects Chesapeake to Huntington, West Virginia.

Ten years later, the four-lane expressway was extended eastward to an incomplete trumpet interchange just east of Big Branch Road.

Phase 1-B was designated from Irene Road to State Route 7 near Fairland East Elementary in Rome Township.

[16] The $6.5 million,[14] one-mile (1.6 km) section of three-lane roadway was opened from the foot of the East Huntington Bridge to Irene Road and signed as SR 607.

On June 3, 2003, bids were opened for Phase 1-B from Irene Road to SR 7 near Fairland East Elementary.

Funding which had been previously promised by the Ohio Department of Transportation (ODOT) was later denied.

The bypass was extended east in 2000 from Rock Springs to a partial diamond interchange with SR 7 as a four-lane divided expressway.

The diamond interchange was later completed with all connections, and the highway was extended eastward to Ravenswood, West Virginia as US 33.