Its western terminus is at the Indiana state line approximately 9 miles (14 km) west of Camden at the eastern terminus of Indiana State Road 44; and its eastern terminus is at US 42 just south of Spring Valley.

[4] The portion of SR 725 between Union Road and Soldiers Home Road in Miamisburg is designated as the "SGT Gary Lee McKiddy Memorial Highway",[5] in honor of a 1968 Miamisburg High School graduate and U.S. Army sergeant.

On May 6, 1970, McKiddy, a 20-year-old member of the 1st Squadron, 9th Cavalry Regiment, 1st Cavalry Division, was serving in Cambodia during the Vietnam War; on that date, he pulled a fellow soldier from a burning helicopter; McKiddy then returned to the helicopter in an attempt to rescue the pilot; as he did, the helicopter exploded, killing both McKiddy and the pilot.

[6] The portion of SR 725 between Heincke Road and SR 741 in Miamisburg is designated as the "Marine Corporal Paul W. Zanowick II Memorial Highway",[7] in honor of a Miamisburg High School graduate, nicknamed "Rocky", who was killed in Nahre Saraj District, Helmand Province, Afghanistan on June 3, 2011.

[2][3] In 1939, the route was extended east to US 42 in Spring Valley.