State Route 741’s northern terminus is at a partial interchange with I-75 at its Exit 50B in Moraine, just south of Dayton.

Created in the late 1930s, State Route 741 passes through the counties of Warren and Montgomery.

[3][4] By 1971, State Route 741 was extended north along Springboro Pike from Dixie Drive up to its current northern terminus at Interstate 75 in Moraine.

[7][8] On June 4, 2010, a continuous-flow intersection (CFI), the first of its kind in Ohio, was built at SR 741 and Austin Boulevard (the former Miamisburg-Springboro Pike/Austin Pike) in southern Montgomery County.

There are some suggestions that a full CFI was not built in order to allow land which would have been used for right-of-way to instead be retained by developers.