Routes 73 and 350 formed a concurrency 1,300 feet (0.40 km) northwest of the southern terminus; the routes together head southeast to New Vienna.

In the center of Sabina, the route intersects US 22 / SR 3 (Washington Street).

The route then passes through more farmland, enters Fayette County, crosses the Rattlesnake Creek, and makes another sharp left turn at Palmer Road (County Road 11).

[2] The route goes through more flat farmland before crossing over I-71 without an interchange and entering the village limits of Jeffersonville.

North of Jeffersonville, the route makes three more 90-degree S-curves before entering Madison County.