The western terminus of SR 435 is at a partial interchange with U.S. Route 35 (US 35) approximately 5.50 miles (8.85 km) southwest of Jeffersonville, and its eastern terminus is a T-intersection with SR 729 nearly 2 miles (3.2 km) northeast of Milledgeville.

SR 435 provides access between current U.S. Route 35 and Interstate 71 (I-71), as no direct interchange exists between the two highways.

The NHS is a network of routes identified as being most important for the economy, mobility and defense of the nation.

Consequently, the majority of the former two-lane routing was removed from the state highway system.

Instead,[citation needed] the city of Kent and Brimfield Township expanded SR 43 from two lanes to four to provide better access to I-76.