Its southern terminus is at the concurrency of U.S. Route 33 (US 33) and SR 161 in Dublin, and it runs for approximately ten miles (16 km) to Concord Township in Delaware County, where it arrives at its northern terminus at the concurrency of US 42 and SR 257.

Running north from there, the two-lane state highway passes through a residential portion of the northwestern Columbus suburb.

Entering into Shawnee Hills, the state highway passes through a primarily commercial district, in parallel to the reservoir.

SR 745 departs Shawnee Hills, and as it enters into rural Concord Township, it meets Harriott Drive, then crosses over a western arm of the O'Shaughnessy Reservoir.

Now passing amidst a rural backdrop with a mix of woods, farmland and occasional houses, SR 745 intersects Duffy Road and Moore Road prior to arriving at its northern terminus, a signalized intersection with US 42 and SR 257 in Concord Township.