Its southern terminus is at U.S. Route 42 (US 42) approximately three miles (4.8 km) north of Ashley, and its northern terminus is at SR 309 in Caledonia.

The majority of SR 746's route lies within rural territory, passing amid a vastness of farmland.

Beginning at the intersection of US 42 and County Road 155 (CR 155) in Westfield Township, Morrow County, SR 746 runs westerly for a short distance, crossing CR 156 before turning north at the CR 153 intersection.

Running inside of the Morrow–Marion county line by approximately one-quarter mile (0.40 km), SR 746 continues northerly past intersections with CR 123 and CR 154 prior to intersecting SR 529.

North of there, SR 746 meets SR 95, then crosses Roberts Road and Marion-Williamsport Road before bending to the northwest as it goes over the Olentangy River.