This sitcom revolves around the adventures and misadventures in the life of Dr. Aga, a young veterinarian who has inherited his brother's children.
He lives with his best friend and "kinakapatid" Godo in the duplex that is in a compound owned by Don Berto Makunatan a.k.a.
Few years later, Aga and his friends were forced to leave their former home due to the demolition and make way for the construction of a flyover.
In their new community, they are joined by their new neighbors, friends and acquaintances including Alfredo (Ching Arellano) and Dyords (Carmina Villarroel).
Claudine Barretto left Oki Doki Doc during the later years due to her busy schedules in soap operas and films.