The district borders Arkansas, Kansas, Missouri, and Texas and includes (in whole or in part) a total of 24 counties.

[3] With a Cook Partisan Voting Index rating of R+29, it is the most Republican district in Oklahoma, a state with an all-Republican congressional delegation.

The district borders Kansas to the north, Missouri and Arkansas to the east, and Texas (along the Red River) to the south.

It includes the remainder of Rogers County (including the county seat of Claremore) that is not included in the 1st district, and then, also, all of the following counties: Adair, Nowata, Craig, Ottawa, Mayes, Delaware, Cherokee, Okmulgee, Muskogee, Sequoyah, Okfuskee, McIntosh, Haskell, LeFlore, Hughes, Pittsburg, Latimer, Coal, Atoka, Pushmataha, McCurtain, Choctaw, Bryan, Marshall and Johnston.

[3] Some of the principal cities in the district include Miami, Claremore, Muskogee, Tahlequah, Okmulgee, McAlester, and Durant.

Since the 2012 election, the 2nd district has been safely Republican at all levels including the House: it was represented by Markwayne Mullin from 2013.