[2] In 2008, the school occupied its permanent building, located at 1301 NE 101st Street in Oklahoma City.

On January 22, 2019, Oklahoma City Public Schools Superintendent Sean McDaniel announced that Centennial would be closed as a part of his "Path to Greatness" plan.

Beginning in 2011, H. Charmaine Johnson was appointed as Oklahoma Centennial High School's principal.

As part of the "Pathway to Greatness" program, OCHS was selected as one of the schools that was to close down permanently.

It closed at the end of June in 2019, and Harding Charter Preparatory High School began to occupy its building instead.