From the terminus at State Highway 31, SH-131 heads northeast towards the unincorporated town of Cairo.

North of Phillips Hollow, the route crosses a small stream, an eventual tributary of Coal Creek.

After entering Atoka County, the highway gradually curves onto an east-northeast course, which continues as it passes through Wardville, another incorporated town 8 miles (13 km)[4] northeast of Cairo.

[5] Five miles (8.0 km)[4] east of Wardville, it ends at US-69 south of Kiowa.

When it was originally commissioned, it began at its present-day western terminus near Cairo, but stopped short of the present-day eastern terminus, instead ending in Wardville.