SH-132 begins at State Highway 51 in rural Kingfisher County three miles (4.8 km) east of the unincorporated community of Lacey.

Five miles (8.0 km) north of Barr, the road skirts the east edge of Drummond, where it crosses a Grainbelt Corporation railroad track.

[5] North of Carrier, the highway crosses another railroad track, this one operated by Burlington Northern Santa Fe, before running to the west of Hillsdale.

From here, the highway continues due north, passing west of Sand Creek, Wakita, and Gibbon en route to Manchester.

A minor realignment to the highway occurred in southern Grant County on January 7, 1963, the final change to SH-132's route.

[1] By 1963, the portion of highway in Grant County south of US-64 was paved, leaving only a section extending from north of Nash to SH-11 as unpaved.